Is Des Safe For Dogs?

What is a DES daughter?

DES Daughters are defined as women born between 1938 and 1971 who were exposed to DES before birth (in the womb).

Research has confirmed that DES Daughters are at an increased risk for: Clear cell adenocarcinoma (CCA), a rare kind of vaginal and cervical cancer..

What is DES used for in dogs?

Diethylstilbestrol (DES) is a synthetic female hormone that is used to treat urinary incontinence in spayed female dogs. It mimics the effects of the natural female hormone, estrogen. DES is also used in the treatment of some cancers in both male and female dogs.

How long does it take for DES to work in dogs?

It is orally bioavailable and reaches peak plasma concentrations in 1 hr in dogs; it has an elimination half-life of 24 hr because of enterohepatic recirculation. Estrogens sensitize the urethral sphincter to α-adrenergic stimulation; therefore, DES therapy is synergistic with α-adrenergic drugs.

Why is my dog suddenly incontinent?

Disease-Related Incontinence Bladder infections, tumors, stones, and cancer may cause incontinence in male as well as female dogs by causing a sudden, uncontrollable urge to urinate. In some cases, urinary problems may even lead to a diagnosis of spinal cord disease as the nerve impulses to the bladder can be affected.

When was Des banned?

Throughout 1971, researchers published more studies that linked DES to the development of irregularities in the glands of the daughters of DES users and, in November of 1971, the FDA banned the use of DES during pregnancy in the US.

What can I give my dog for incontinence?

The US Food and Drug Administration (FDA) last week approved Proin ER (phenylpropanolamine hydrochloride extended release), a tablet for the control of urinary incontinence in dogs. The drug will aid with urethral sphincter hypotonus, which occurs due to a dog’s age and weakening muscles in the urethra.

What can I give my dog for a weak bladder?

Treatment for incontinence will depend on its underlying cause. Medications can often effectively manage this condition and prevent everyday accidents. Some treatments focus on hormone therapy, while others, such as phenylpropanolamine, strengthen the urethral sphincter, which controls urine flow.

Is Des still used?

Many people who were exposed to DES as a fetus still don’t know it. Estrogens are still prescribed for some medical reasons, including to help treat some cancers, but they are no longer used during pregnancy. Other than in a rare clinical trial, DES is no longer available in the United States for use in humans.

What is Des syndrome?

Diethylstilbestrol syndrome (DES syndrome) refers to developmental or health problems caused by exposure to DES before birth (in utero), such as reproductive tract differences, infertility, and an increased risk for certain cancers .

What are the side effects of diethylstilbestrol?

Because of the potential toxic side-effects of estrogen use, it is always important to use the lowest effective dose for the shortest period of time. Other side-effects include signs of estrus, lethargy, diarrhea, vomiting, vaginal discharge, pyometra, polydipsia, polyuria, and feminization of male dogs.

Is Stilbestrol safe for dogs?

DOGS: 1 mg per 10 kg / CATS: 0.5 mg per 5 kg; Given orally once daily for 1 week or until incontinence is resolved (no longer than 7 days), then gradually reduce dosage until lowest effective dose is attained for maintenance. CONTRA-INDICATIONS: Do not use in females with estrogen-sensitive neoplasms.

What helps incontinence in dogs naturally?

Garlic: As a natural antibiotic. Echinacea: To assist in the removal of residual products of infection. Rosehips: As a primary Kidney tonic and a high source of Iron and Vitamin C. Buchu: As a specific UTI treatment and blood cleanser.